Puzzle and Challenge in Differentiating Immunoglobulin G4-related Cholangitis from Hilar Cholangiocarcinoma
نویسندگان
چکیده
Under normal conditions, IAC is often misdiagnosed as cholangiocarcinoma because these two diseases share almost the same clinical features. Importantly, IAC is a benign disease that can be treated by steroids, while hilar cholangiocarcinoma is a malignant disease that requires curative surgery. Research has revealed cases of misdiagnosis of IAC with biliary carcinoma who underwent unnecessary invasive surgery.[2] Thus, currently, it is a challenge to differentiate IAC accurately from carcinomas preoperatively and choose the appropriate treatment.
منابع مشابه
Hilar cholangiocarcinoma associated with immunoglobulin G4‐positive plasma cells and elevated serum immunoglobulin G4 levels
Immunoglobulin G4 (IgG4)-related disease is a fibroinflammatory systemic disorder with multiorgan involvement. Proximal bile duct involvement results in IgG4-related sclerosing cholangitis, which is characterized by a lymphoplasmacytic infiltrate with abundant IgG4-positive plasma cells and fibrosis. Differentiating between cholangiocarcinoma and IgG4-sclerosing cholangitis can present a diagno...
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BACKGROUND/AIMS Few studies have differentiated immunoglobulin G (IgG) 4-related sclerosing cholangitis (IgG4-SC) from hilar cholangiocarcinoma (CC). Thus, we sought to investigate useful features for differentiating IgG4-SC from hilar CC. METHODS We retrospectively compared clinical, serological, imaging, and histological features of six patients with IgG4-SC and 42 patients with hilar CC. ...
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Immunoglobulin G4-related lymphoplasmacytic sclerosing disease is an emerging disease. Recently, it has been shown to be responsible for autoimmune pancreatitis-induced strictures of the bile duct mimicking cholangiocarcinoma. Making a diagnosis of immunoglobulin G4-associated sclerosing cholangitis requires a high index of suspicion. The differential diagnoses include primary sclerosing cholan...
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